Research
There are numerous reports on potential applications for PRP and BMC in the basic science and clinical research literature, and that body of evidence continues to grow. Unfortunately, a significant majority of both clinical utilization and research of PRP and BMC used products which had very little quality control and very few cell counts.
At Karli Health, we believe that not knowing exactly what is being put into a patient during a cell therapy is unacceptable. Only through careful measurement, data collection and study of dose response relationships can we learn to further optimize and customize our product for both the patient being treated and the problem we are targeting.
Greyledge has created a novel web-based data collection and management system that allows clinical partners like the Karli Health to capture this critical data before, during and after treatment. Data from our products and patient reported results of treatment can then be analyzed through application of AI (artificial intelligence) and ML (machine learning) algorithms that will speed up and enhance our ability to learn from every product made and every patient treated to advance the field of cellular therapies and apply what we learn to continually make our products and the delivery of them better in time.
Below is a list of possible illnesses and injuries where autologous preparations have been reported for treating a wide variety of pathologies with links to references provided.
Reference index
Osteoarthritic Joint Pain
- Kon E, et al. (2010) Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions. View Resource
- Khoshbin A, et al. (2013) The efficacy of platelet-rich plasma in the treatment of symptomatic knee osteoarthritis: a systematic review with quantitative synthesis. View Resource
- Sánchez M, et al. (2012) Ultrasound-guided platelet-rich plasma injections for the treatment of osteoarthritis of the hip. View Resource
- Centeno C, et al. (2016) A dose response analysis of a specific bone marrow concentrate treatment protocol for knee osteoarthritis. View Resource
- Fortier LA, et al. (2010) Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with microfracture in an equine model. View Resource
- Milano G, et al. (2010) The effect of platelet rich plasma combined with microfractures on the treatment of chondral defects: an experimental study in a sheep model. View Resource
- Buda R, et al. (2015) One-step bone marrow-derived cell transplantation in talar osteochondral lesions: mid-term results. View Resource
- Foster TE, et al. (2009) Platelet-rich plasma: from basic science to clinical application. View Resource
- Murray MM, et al. (2009) Enhanced histologic repair in a central wound in the anterior cruciate ligament with a collagen–platelet-rich plasma scaffold. View Resource
- Braun HJ, et al. (2013) The Use of PRP in ligament and meniscal healing. View Resource
- Yu H, et al. (2015) Meniscus repair using mesenchymal stem cells – a comprehensive review. View Resource
- Cook JL, et al. (2016) Multiple injections of leukoreduced platelet rich plasma reduce pain and functional impairment in a canine model of ACL and meniscal deficiency. View Resource
Muscle and Tendon Injuries
- Peerbooms JC, (2010) Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet-rich plasma versus corticosteroid injection with a 1-Year follow-up. View Resource
- Gosens T, et al. (2011) Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: a double-blind randomized controlled trial with 2-year follow-up. View Resource
- Mishra A, et al. (2014) Efficacy of platelet-rich plasma for chronic tennis elbow: a double-blind, prospective, multicenter, randomized controlled trial of 230 patients. View Resource
- Cervellin M, et al. (2012) Autologous platelet-rich plasma gel to reduce donor-site morbidity after patellar tendon graft harvesting for anterior cruciate ligament reconstruction: a randomized, controlled clinical study. View Resource
- Di Matteo B, et al. (2015) Platelet-rich plasma: evidence for the treatment of patellar and Achilles tendinopathy—a systematic review. View Resource
- Pascual-Garrido C, et al. (2012) Treatment of chronic patellar tendinopathy with autologous bone marrow stem cells: a 5-year followup. View Resource
- Randelli P, et al. (2011) Platelet rich plasma in arthroscopic rotator cuff repair: a prospective RCT study, 2-year follow-up. View Resource
- Hernigou P, et al. (2014) Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study. View Resource
- Sanchez M, et al. (2007) Comparison of surgically repaired Achilles tendon tears using platelet rich fibrin matrices. View Resource
- Stein BE, et al. (2015) Outcomes of acute Achilles tendon rupture repair with bone marrow aspirate concentrate augmentation. View Resource
- Galasso O, et al. (2008) Expandable intramedullary nailing and platelet rich plasma to treat long bone non-unions. View Resource
- Sampson S, et al. (2008) Platelet rich plasma injection grafts for musculoskeletal injuries: a review. View Resource
- Pettine K, et al. (2016) Treatment of discogenic back pain with autologous bone marrow concentrate injection with minimum two year follow-up. View Resource
- Monfett M, et al. (2016) Intradiscal platelet-rich plasma (PRP) injections for discogenic low back pain: an update. View Resource
- Man D, et al. (2001) The use of autologous platelet-rich plasma (platelet gel) and autologous platelet-poor plasma (fibrin glue) in cosmetic surgery. View Resource
- Cervelli V, et al. (2009) Application of platelet-rich plasma in plastic surgery: clinical and in-vitro evaluation. View Resource
- Redaelli A, et al. (2010) Face and neck revitalization with platelet-rich plasma (PRP): clinical outcome in a series of 23 consecutively treated patients. View Resource
- Sclafani AP, and SA McCormick. (2012) Induction of dermal collagenesis, angiogenesis, and adipogenesis in human skin by injection of platelet-rich fibrin matrix. View Resource
- Lee JW, et al. (2011) The Efficacy of autologous platelet rich plasma combined with ablative carbon dioxide fractional resurfacing for acne scars: A Simultaneous Split-Face Trial. View Resource
- Cho JM, et al. (2011) Effect of platelet-rich plasma on ultraviolet b-induced skin wrinkles in nude mice. View Resource
- Shin MK, et al. (2012) Platelet-rich plasma combined with fractional laser therapy for skin rejuvenation. View Resource
- Tateishi-Yuyama E, et al. (2002) Therapeutic angiogenesis for patients with limb ischemia by autologous transplantation of bone-marrow cells: a pilot study and a randomized controlled trial. View Resource
- Bartsch T, et al. (2007) Transplantation of autologous mononuclear bone marrow stem cells in patients with peripheral arterial disease (the TAM-PAD study). View Resource
- Amann B, et al. (2009) Autologous bone marrow cell transplantation increases leg perfusion and reduces amputations in patients with advanced critical limb ischemia due to peripheral artery disease. View Resource
- Fadnini GP, et al. (2010) Autologous stem cell therapy for peripheral arterial disease: Meta-analysis and systemic review of the literature. View Resource
- Molavi B, et al. (2016) Safety and Efficacy of Repeated Bone Marrow Mononuclear Cell Therapy in Patients with Critical Limb Ischemia in a Pilot Randomized Controlled Trial. View Resource
- Marx RE. Platelet-rich plasma: evidence to support its use. View Resource
- Sammartino G, et al. (2005) Use of autologous platelet-rich plasma in periodontal defect treatment after extraction of impacted mandibular third molars. View Resource
- Bajaj P, et al. (2013) Comparative evaluation of autologous platelet-rich fibrin and platelet-rich plasma in the treatment of mandibular degree II furcation defects: a randomized controlled clinical trial. View Resource
- Hom DB, et al. (2007) The healing effects of autologous platelet gel on acute human skins wounds. View Resource
- Driver VR, et al. (2006) A prospective, randomized, controlled trial of autologous platelet-rich plasma gel for the treatment of diabetic foot ulcers. View Resource
- Kazakos K, et al. (2009) The use of autologous PRP gel as an aid in the management of trauma wounds. View Resource
- Carter MJ, et al. (2011) Use of platelet-rich plasma gel on wound healing: a systematic review and meta-analysis. View Resource
- Saad Setta, H, et al. (2011) Platelet-rich plasma versus platelet-poor plasma in the management of chronic diabetic foot ulcers: a comparative study. View Resource
- Dabiri G, et al. (2013) The emerging use of bone marrow-derived mesenchymal stem cells in the treatment of human chronic wounds. View Resource
- Murphy M, et al. (2013) Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine. View Resource
- Cassano JM, et al. (2016) Bone marrow concentrate and platelet-rich plasma differ in cell distribution and interleukin 1 receptor antagonist protein concentration. View Resource
- Wang SW, et al. (2014) Identification of α2-Macroglobulin as a Master Inhibitor of Cartilage-Degrading Factors That Attenuates the Progression of Posttraumatic Osteoarthritis. View Resource
- Cicha I, et al. (2004) Activated human platelets release connective tissue growth factor. View Resource
- De Mos M, et al. (2008) Can platelet-rich plasma enhance tendon repair? View Resource
- Evans, C. (1999) Cytokines and the role they play in the healing of ligaments and tendons. View Resource
- Kumar V, and JR Chapman. (2008) Autologous thrombin: intraoperative production from whole blood. View Resource
- Marx RE, et al. (1998) Platelet-rich plasma: growth factor enhancement for bone grafts. View Resource
- Weibrich G, et al. (2004) Effect of platelet concentration in platelet-rich plasma on the peri-implant bone regeneration. View Resource
- Zechner W, et al. (2003) Influence of platelet-rich plasma on osseus healing of dental implants: a histologic and histomorphometric study in minipigs. View Resource
- Woodell-May J, et al. (2011) Autologous protein solution inhibits MMP-13 production by IL-1β and TNFα-stimulated human articular chondrocytes. View Resource
- van Buul GM, et al. (2011) Platelet-rich plasma releasate inhibits inflammatory processes in osteoarthritic chondrocytes. View Resource